The V-ATPase/ATG16L1 axis is controlled by the V1H subunit

Organelle ATG16L1 ATG8
DOI: 10.1016/j.molcel.2024.07.003 Publication Date: 2024-07-31T14:39:02Z
ABSTRACT
Defects in organellar acidification indicate compromised or infected compartments. Recruitment of the autophagy-related ATG16L1 complex to pathologically neutralized organelles targets ubiquitin-like ATG8 molecules perturbed membranes. How this process is coupled proton gradient disruption unclear. Here, we reveal that V
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