The V-ATPase/ATG16L1 axis is controlled by the V1H subunit

• DOI: 10.1016/j.molcel.2024.07.003
• Publication Date: 2024-07-31T14:39:02Z
• Authors: Lewis Timimi; Antoni G. Wrobel; George N. Chiduza; Sarah L. Maslen; Antonio Torres-Mé...; Beatriz Montaner; Colin Davis; Taylor Minckley; Katriona L. Hole; Andrea Serio; Michael J. Devine; J. Mark Skehel; John L. Rubinstein; Anne Schreiber; Rupert Beale
• Keywords: Organelle; ATG16L1; ATG8

Defects in organellar acidification indicate compromised or infected compartments. Recruitment of the autophagy-related ATG16L1 complex to pathologically neutralized organelles targets ubiquitin-like ATG8 molecules perturbed membranes. How this process is coupled proton gradient disruption unclear. Here, we reveal that V