Solubilities of formononetin and daidzein in organic solvents: Effect of molecular structure and interaction on solvation process

• DOI: 10.1016/j.molliq.2017.02.051
• Publication Date: 2017-02-16T13:31:51Z
• Authors: Xinyan Dong; Yifeng Cao; Humin Lin; Yi Yao; Yi Guo; Tao Wang; Sundu Wu; Zhige Wu
• Keywords: 02 engineering and technology; 0204 chemical engineering

Abstract The solubilities of formononetin and daidzein in methanol, ethanol, n-propanol, isopropanol and acetone were measured by a static equilibrium method at temperatures range from 293.2 to 323.2 K. The solubilities of formononetin and daidzein increased with rising temperature. At a given temperature, the solubility expressed in mole fraction was recorded highest in acetone (e. g., 5.2735 × 10–4 for formononetin and 7.4678 × 10–4 for daidzein at T = 293.2 K, respectively.) followed by n-propanol, isopropanol , ethanol, and methanol, and the solubility in different solvents mainly depended on the polarity and hydrogen-bond acceptor (HBA) basicity of the solvents. Moreover, the experimental solubility data in all solvents could be reasonably correlated by ideal model, the modified Apelblat equation, λh equation and van't Hoff equation (the relative average deviations (RAD)were all