Carbonyl reductase 1 amplifies glucocorticoid action in adipose tissue and impairs glucose tolerance in lean mice

• DOI: 10.1016/j.molmet.2021.101225
• Publication Date: 2021-03-27T08:52:16Z
• Authors: Rachel M.B. Bell; Elisa Villalobos; Mark Nixon; Allende Miguelez-...; Lee Murphy; Angie Fawkes; Audrey Coutts; Matthew G.F. Sharp; Martha V. Koerner; Emma Allan; Onno C. Meijer; Renè Houtman; Alex Odermatt; Katharina R. Beck; Scott G. Denham; Patricia Lee; Natalie Z.M. Homer; Brian R. Walker; Ruth A. Morgan
• Keywords: Corticosterone; Mineralocorticoid

Carbonyl reductase 1 (Cbr1), a recently discovered contributor to tissue glucocorticoid metabolism converting corticosterone 20β-dihydrocorticosterone (20β-DHB), is upregulated in adipose of obese humans and mice may contribute cardiometabolic complications obesity. This study tested the hypothesis that Cbr1-mediated influences mineralocorticoid receptor activation impacts glucose homeostasis lean states.