Loss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in mice

• DOI: 10.1016/j.molmet.2024.101915
• Publication Date: 2024-03-14T08:15:48Z
• Authors: Seun Akindehin; Arkadiusz Liskiewicz; Daniela Liskiewicz; Miriam Bernecker; Cristina Garcia-C...; Daniel J. Drucker; Brian Finan; Gerald Grandl; Robert Gutgesell; Susanna M. Hofmann; Ahmed Khalil; Xue Liu; Perla Cota; Mostafa Bakhti; Oliver Czarnecki; Aimée Bastidas-Ponce; Heiko Lickert; Lingru Kang; Gandhari Maity; Aaron Novikoff; Sebastian Parlee; Ekta Pathak; Sonja C. Schriever; Michael Sterr; Siegfried Ussar; Qian Zhang; Richard DiMarchi; Matthias H. Tschöp; Paul T. Pfluger; Jonathan D. Douros; Timo D. Müller
• Keywords: Leptin receptor; Gastric inhibitory polypeptide

The glucose-dependent insulinotropic polypeptide (GIP) decreases body weight via central GIP receptor (GIPR) signaling, but the underlying mechanisms remain largely unknown. Here, we assessed whether regulates and glucose control GIPR signaling in cells that express leptin (Lepr).