Regioselective synthesis of novel 3-allyl-2-(substituted imino)-4-phenyl-3H-thiazole and 2,2′-(1,3-phenylene)bis(3-substituted-2-imino-4-phenyl-3H-thiazole) derivatives as antibacterial agents

• DOI: 10.1016/j.molstruc.2013.02.003
• Publication Date: 2013-02-14T04:31:36Z
• Authors: Jafar Abbasi Shiran; Asieh Yahyazadeh; Manouchehr Mamaghani; Mehdi Rassa
• Keywords: Thiazole; Micrococcus luteus; Salmonella enterica

Abstract Several novel 3-allyl-2-(substituted imino)-4-phenyl-3 H -thiazole derivatives were synthesized by the reaction of allyl-thioureas and 2-bromoacetophenone. We also report the synthesis of bis-allyl-3 H thiazoles using the reaction of various isothiocyanates and 1,3-phenylenediamine. The structures of all compounds were characterized by spectral and elemental analysis. Most of the synthesized compounds exhibited efficient antibacterial activities against Salmonella enterica , Micrococcus luteus , Bacillus subtilis and Pseudomonas aeruginosa.