Dietary factors and MRI metrics in early Multiple Sclerosis

• DOI: 10.1016/j.msard.2021.103031
• Publication Date: 2021-05-19T05:08:19Z
• Authors: I.B. Katz Sand; Kathryn C. Fitzge...; Yian Gu; Rachel Brandstadter; Claire S. Riley; Korhan Buyukturkoglu; Victoria M. Leavitt; Stephen Krieger; Aaron Miller; Fred Lublin; Sylvia Klineova; Michelle Fabian; James F. Sumowski
• Keywords: Benchmarking; 03 medical and health sciences; Cross-Sectional Studies; Multiple Sclerosis; 0302 clinical medicine; Humans; Diet, Mediterranean; Magnetic Resonance Imaging

Despite significant interest in diet by the MS community, research on this topic is limited; there are no published studies evaluating associations between and neuroimaging MS.We utilized baseline data from RADIEMS cohort of early (diagnosed <5.0 years, n=180). Participants underwent brain MRIs to derive normalized total gray thalamic volumes, T2 lesion volume, white matter microstructural integrity normal appearing (NAWM). completed food frequency questionnaires (FFQ) which we calculated adherence scores pre-specified dietary patterns including Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet. We evaluated intake following components: fruits, vegetables, legumes, nuts, whole grains, dairy, fried foods, processed meats, fat intake. used multivariable-adjusted linear regression evaluate MRI metrics versus measures.MIND score was associated with volume; individuals highest quartile MIND had greater volumes those lowest (Q4 vs. Q1: 1.03mL; 95%CI: 0.26mL, 1.79mL; p<0.01). For individual food/nutrients, higher intakes full-fat dairy were lower -0.93mL; -1.51mL, -0.35ml; Higher marine omega-3 fatty acids NAWM 0.40; 0.03, 0.76; p=0.04). Other foods/nutrients not outcomes.In first study focused MS, note a cross-sectional cohort. Longitudinal follow-up imaging/clinical outcomes will provide additional insights.