Fatigue and health-related quality of life depend on the disability status and clinical course in RRMS

• DOI: 10.1016/j.msard.2023.104861
• Publication Date: 2023-07-05T01:19:27Z
• Authors: Henrik Ahvenjärvi; Marja Niiranen; Sakari Simula; Päivi Hämäläinen; Heljä-Marja Surcel; Anne M Remes; Mervi Ryytty; Johanna Krüger
• Keywords: Quality of life; Multiple Sclerosis; Neurosciences; 3. Good health; Multiple sclerosis; Cross-Sectional Studies; Multiple Sclerosis, Relapsing-Remitting; Quality of Life; Disease Progression; Humans; 10. No inequality; ta515; Fatigue; Retrospective Studies

Background: Fatigue is a prominent and disabling symptom of multiple sclerosis (MS), impairing quality life. The disease course relapsing remitting MS (RRMS) individual.ObjectivesWe aimed to study the effects demographic clinical characteristics, as well lifestyle risk factors on experienced fatigue health-related life (HRQoL) among RRMS patients, comparing benign severe types.MethodsAltogether 198 Finnish patients were recruited for this real-life cross-sectional study. Self-reported questionnaires used evaluate by using Scale Motor Cognitive Functions 15D questionnaires. Patients categorized into subgroups based current disability status measured Expanded Disability Status (EDSS) cut-off value 4.5, retrospective divided aggressive RRMS.ResultsAll in all, 73% suffered from fatigue. Lower HRQoL had strong correlation with more (r = -0.719). Higher EDSS was associated lower whole cohort. Older age at onset decreased groups > 4.5. In ≤ 4.5 RRMS, higher number disease-modifying treatments (DMTs) pronounced reduced HRQoL. addition, BMI RRMS. Side (45 %) lack efficacy (26 most common reasons discontinuing DMT. Cessation due side only reason that significantly Use nicotine products, gender, or duration not HRQoL.ConclusionsIndividuals scores are prone experience commonly observed older those DMT switches.