Multifunctional bioactive glass scaffolds coated with layers of poly(d,l-lactide-co-glycolide) and poly(n-isopropylacrylamide-co-acrylic acid) microgels loaded with vancomycin

• DOI: 10.1016/j.msec.2013.05.002
• Publication Date: 2013-05-09T06:17:29Z
• Authors: B. Olalde; N. Garmendia; V. Sáez-Martínez; N. Argarate; P. Nooeaid; F. Morin; A.R. Boccaccini
• Keywords: PLGA; Biopolymer; Acrylic acid; Poly(N-isopropylacrylamide); Simulated body fluid; Lactide

A new family of multifunctional scaffolds, incorporating selected biopolymer coatings on basic Bioglass® derived foams has been developed. The polymer coatings were investigated as carrier of vancomycin which is a suitable drug to impart antibiotic function to the scaffolds. It has been proved that coating with PLGA (poly(lactic-co-glycolic acid)) with dispersed vancomycin-loaded microgels provides a rapid delivery of drug to give antibacterial effects at the wound site and a further sustained release to aid mid to long-term healing. Furthermore, the microgels also improved the bioactivity of the scaffolds by acting as nucleation sites for the formation of HA crystals in simulated body fluid.