Host–guest system of hesperetin and β-cyclodextrin or its derivatives: Preparation, characterization, inclusion mode, solubilization and stability

• DOI: 10.1016/j.msec.2015.10.037
• Publication Date: 2015-10-25T14:14:27Z
• Authors: Li-Juan Yang; Sha Xia; Shui-Xian Ma; Shu-Ya Zhou; Xue-Qiu Zhao; Shu-Hui Wang; Min-Yan Li; Xiao-Dong Yang
• Keywords: 0301 basic medicine; Cyclodextrins; 03 medical and health sciences; Drug Stability; Solubility; Hesperidin; Nuclear Magnetic Resonance, Biomolecular

The inclusion complexation behavior, characterization and binding ability of hesperetin with β-cyclodextrin and its derivatives were investigated in both the solution and solid state by means of XRD, DSC, SEM, (1)H and 2D NMR and UV-vis spectroscopy. The results showed that the water solubility and stability of hesperetin were obviously increased in the inclusion complex with cyclodextrins. This satisfactory water solubility and high stability of the hesperetin/CD complexes will be potentially useful for their application as herbal medicines or healthcare products.