Nanographene enfolded AuNPs sophisticatedly synchronized polycaprolactone based electrospun nanofibre scaffold for peripheral nerve regeneration

• DOI: 10.1016/j.msec.2020.111213
• Publication Date: 2020-06-20T13:23:42Z
• Authors: Richa Jaswal; Sita Shrestha; Bishnu Kumar Shre...; Dinesh Kumar; Chan Hee Park; Cheol Sang Kim
• Keywords: Tissue Engineering; Tissue Scaffolds; Polyesters; Nanofibers; Metal Nanoparticles; Gold; Peripheral Nerves; 02 engineering and technology; 0210 nano-technology; 01 natural sciences; Cell Proliferation; Nerve Regeneration; 0104 chemical sciences

Herein, we report the bioactivity of monodispersed nanosized reduced graphene oxide (RGO) enfolded gold nanoparticles (AuNPs) engineered polycaprolactone (PCL) based electrospun composite scaffolds. The 2D patterns of PCL based nanofibers prepared by the homogenous distribution of RGO-AuNPs exhibited unique topological and biological features such as mechanical properties, porous structure, large surface area, high electrical conductivity, biodegradability, and resemble the natural extracellular matrix (ECM) that supports the adhesion, growth, proliferation, and differentiation of stem cells. The prepared composite nanofibers based scaffolds containing RGO-AuNPs accelerated neuronal cell functions and confirmed that the optimized concentration showed cytocompatibility to PC12 and S42 cells. The 0.0005 wt% loading of RGO-AuNPs on PCL has a huge impact on neurite growth which leads to an almost one-fold increase in neurite length growth. The present study provides a new strategic design of highly efficient scaffolds that have a significant direct impact on cell activity and could be a potential bioimplant for peripheral nerve repair.