Cobalt-doped layered hydroxide coating on titanium implants promotes vascularization and osteogenesis for accelerated fracture healing

• DOI: 10.1016/j.mtbio.2023.100912
• Publication Date: 2023-12-21T10:47:21Z
• Authors: Xiaodong Chen; Shuohan He; Yilong Dong; Maohua Chen; Zengzilu Xia; Kaiyong Cai; Yan Hu
• Keywords: 0301 basic medicine; Ti implants; Medicine (General); 03 medical and health sciences; R5-920; Osseointegration; QH301-705.5; Full Length Article; Layered hydroxide coating; Angiogenesis; Biology (General); Bone defect repair

Angiogenesis at the fracture site plays crucial roles in endogenous osteogenesis process and is a prerequisite for efficient repair of implant fixed bone defects. To improve peri-implant vascularization titanium accelerating defect healing, we developed Co-doped Mg-Al layered hydroxide coating on surface using hydrothermal reaction then modified with gallic acid (Ti-LDH/GA). Gallic enabled sustained release Co