Potent cancer therapy by liposome microstructure tailoring with active-to-passive targeting and shell-to-core thermosensitive features

• DOI: 10.1016/j.mtbio.2024.101035
• Publication Date: 2024-03-21T00:54:50Z
• Authors: Mengxin Zhao; Xiaodong Zhu; Bailing Li; Chenyang Yan; Cong Wu; Lei He; Jingyi Cao; Fanglin Lu; Han Chen; Wei Li
• Keywords: Rational design; Targeted drug delivery

Liposomes have been widely studied as drug carriers for clinical application, and the key issue is how to achieve effective delivery through targeting strategies. Even though certain cell-level or EPR effect designs developed, reaching sufficient concentration in intracellular regions remains a challenge due singularity of functionality. Herein, benefiting from unique features tumor tissue cell, dual-thermosensitive dual-targeting liposome (DTSL) was creatively fabricated fine microstructure tailoring, which holds intelligent both tissue-regulated active-to-passive binding membrane-derived homologous-fusion (HF) properties. At micro level, DTSL can actively capture cells accompany enhanced HF stimulated by self-constriction, achieves synergistic promotion tissues cells. As result, this first active-then passive process makes more accurate effective, after dynamic into cells, nucleus undergoes further thermally responsive contraction, fully releasing internal drugs.