Self-assembled metal-phenolic nanocomplexes comprised of green tea catechin for tumor-specific ferroptosis

• DOI: 10.1016/j.mtbio.2024.101040
• Publication Date: 2024-03-24T20:07:10Z
• Authors: Min Wang; Aoling Yu; Wen Han; Jingyi Chen; Chunhua Lu; Xiankun Tu
• Keywords: Biocompatibility; Lipid peroxide

Ferroptosis, a newly discovered form of regulated cell death, has garnered significant attention in the field tumor therapy. However, presence overexpressed glutathione (GSH) and insufficient levels H2O2 microenvironment (TME) hinders occurrence ferroptosis. In response to these challenges, here we have constructed self-assembled nanocomplexes (FeE NPs) utilizing epigallocatechin-3-gallate (EGCG) from green tea polyphenols metal ions (Fe3+) as components. After grafting PEG, (FeE@PEG exhibit good biocompatibility synergistically enhanced tumor-inhibitory properties. FeE@PEG NPs can be disassembled by TME, leading rapid release Fe3+ EGCG. The released produces large amounts toxic •OH Fenton reactions while having minimal impact on normal cells. generated effectively induces lipid peroxidation, which leads ferroptosis Meanwhile, EGCG autoxidize produce H2O2, further promotes production radicals increases peroxide levels. Moreover, also depletes high intracellular GSH, an redox imbalance triggering This study provides new insights into advancing anticancer through rational material design, offering promising avenues for future research.