Asymmetric amyloid deposition in preclinical Alzheimer’s disease: A PET study

• DOI: 10.1016/j.nbas.2022.100048
• Publication Date: 2022-08-26T18:09:07Z
• Authors: Pernille L. Kjeldsen; Peter Parbo; Kim V. Hansen; Joel F.A. Aanerud; Rola Ismail; Peter H. Nissen; Rikke B. Dalby; Malene F. Damholdt; Per Borghammer; David J. Brooks
• Keywords: Amyloid (mycology); Deposition

The typical spatial pattern of amyloid-β (Aβ) in diagnosed Alzheimer's disease (AD) is that a symmetrical hemispheric distribution. However, Aβ may be asymmetrically distributed early stages AD. distribution on PET has previously been explored MCI and AD, but it yet to directly investigated preclinical AD (pAD). We examined how was individuals with pAD using 11C-Pittsburgh Compound B (PiB) PET.In this study, 79 subjects were retrospectively enrolled, including 34 controls, 24 pAD, 21 MCI. All underwent APOE genotyping, 11C-PiB PET, MRI, cognitive testing. differences load, lateralisation, distribution, as well associations between cognition.The asymmetry index (AI) differed groups, having the highest AI compared both controls There no clear lateralisation there non-significant trend towards being more left-lateralised correlations scores or MCI.The most asymmetrical first starts accumulating, then becomes less MCI, when spread further, suggesting pronounced distinguishing factor pAD. Longitudinal studies examining across continuum are needed.