No moderating influence of education on the association between changes in hippocampus volume and memory performance in aging

• DOI: 10.1016/j.nbas.2023.100082
• Publication Date: 2023-06-28T08:54:08Z
• Authors: Martin Lövdén; Amos Pagin; David Bartrés-Faz; Carl-Johan Boraxbekk; Andreas M. Brandm...; Naiara Demnitz; Christian A. Drevon; Klaus P. Ebmeier; Anders M. Fjell; Paolo Ghisletta; Tetiana Gorbach; Ulman Lindenberger; Anna Plachti; Kristine B. Walhovd; Lars Nyberg
• Keywords: Association (psychology); Cognitive reserve; Neurocognitive

Contemporary accounts of factors that may modify the risk for age-related neurocognitive disorders highlight education and its contribution to a cognitive reserve. By this view, individuals with higher educational attainment should show weaker associations between changes in brain cognition than lower attainment. We tested prediction longitudinal data on hippocampus volume episodic memory from 708 middle-aged older using local structural equation modeling. This technique does not require categorization years constrain shape relationships, thereby maximizing chances revealing an effect hippocampus-memory association. The results showed were plausible under assumption there was no influence association change volume. Restricting sample elevated genetic dementia (APOE ε4 carriers) did these results. conclude is inconsistent predictions by reserve theory.