DYNLRB1 is essential for dynein mediated transport and neuronal survival

• DOI: 10.1016/j.nbd.2020.104816
• Publication Date: 2020-02-21T05:40:42Z
• Authors: Marco Terenzio; Agostina Di Pizio; Ida Rishal; Letizia Marvaldi; Pierluigi Di Matteo; Riki Kawaguchi; Giovanni Coppola; Giampietro Schiavo; Elizabeth M.C. Fi...; Mike Fainzilber
• Keywords: Dynactin; Axoplasmic transport; Organelle

The cytoplasmic dynein motor complex transports essential signals and organelles from the cell periphery to perinuclear region, hence is critical for survival function of highly polarized cells such as neurons. Dynein Light Chain Roadblock-Type 1 (DYNLRB1) thought be an accessory subunit required specific cargos, but here we show that it general dynein-mediated transport sensory neuron survival. Homozygous Dynlrb1 null mice are not viable die during early embryonic development. Furthermore, heterozygous or adult knockdown animals display reduced neuronal growth, selective depletion in proprioceptive neurons compromises their Conditional causes deficits several signaling pathways, including β-catenin subcellular localization, a severe impairment axonal both lysosomes retrograde endosomes. Hence, DYNLRB1 component complex, given dynein's functions physiology, could have prominent role etiology human neurodegenerative diseases.