Impact of iron chelation with deferasirox on telomere length and oxidative stress in hemodialysis patients: A randomized study

Deferasirox
DOI: 10.1016/j.nefro.2024.06.006 Publication Date: 2024-06-14T20:37:54Z
ABSTRACT
Background: Recent studies have demonstrated the effectiveness, safety, and tolerability of deferasirox in patients peritoneal dialysis, however, its effect has not been studied undergoing hemodialysis. Objective: To investigate impact iron chelation on telomere length, oxidative stress, ferritin levels Methods: This is an open-label study, with a control group hemodialysis, who will receive treatment 15mg/kg/day for 6 months chelation. Telomere length was measured using real-time PCR. Serum Ferritin oxidation markers were evaluated. evaluate pharmacokinetics safety deferasirox, plasma concentrations analyzed by HPLC. Results: 54 included to 50 patients. Significant differences observed serum (p<0.0001), TBARS (Thiobarbituric Acid Reactive Substances) (p<0.01). had significant increase after (p<0.001). The concentration at zero time 48 hours maintained within range 2.67 23.78 mmol/L. Conclusions: Our results demonstrate that hemodialysis significantly reduces TBARS, resulting length. Deferasirox proves be beneficial overload
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