Copy number variation in triple negative breast cancer samples associated with lymph node metastasis

• DOI: 10.1016/j.neo.2021.05.016
• Publication Date: 2021-07-02T17:42:35Z
• Authors: Mamta Pariyar; Andrea Johns; Rick F. Thorne; Rodney J. Scott; Kelly A. Avery-Ki...
• Keywords: Triple-negative breast cancer

Triple negative breast cancer (TNBC) is a highly metastatic and aggressive subtype of cases presenting with lymph node involvement have worse outcomes. This study aimed to determine the regions copy number variation (CNV) associated metastasis in TNBC patients. CNV analyses were performed cohort 23 invasive ductal carcinomas (IDCs), 12 metastases (LNmets), 7 normal adjacent tissues (NATs); as well an independent containing 70 IDCs same NATs. CNV-associated genes analyzed using GO-enrichment Pathway analysis. The prognostic role for showing CNV-based changes messenger RNA expression was determined Kaplan-Meier plotter database. For IDCs, there variations that common both cohorts amplified 1q, 8q, 19 (p q), 2p, 5p deleted 8p followed by 5q, 19p. most frequently LNmets 4q28.3, 3q24, 1q21.2, 10p, 12p11.1, 20p11.22-20p11.21, 21q22.13, 6p22.1 1p36.23, 4q21.1 5q. A total 686 (441 245 deleted) LNmets. LNmet-associated enriched "regulation complement activation," protein activation cascade," humoral immune response," "oxytocin signalling pathway," "TRAIL binding" pathways. Moreover, 6/686 showed their mRNA which, high ASPM KIF14 significantly relapse-free survival. has identified several could play major node.