Time-restricted feeding affects the fecal microbiome metabolome and its diurnal oscillations in lung cancer mice

• DOI: 10.1016/j.neo.2023.100943
• Publication Date: 2023-10-16T18:43:38Z
• Authors: Gaofeng Fang; Shengquan Wang; Qianyao Chen; Han Luo; Xuemei Lian; Dan Shi
• Keywords: Metabolome

The homeostasis of the gut microbiota and circadian rhythm is critical to host health, both are inextricably intertwined with lung cancer. Although time-restricted feeding (TRF) can maintain synchronization improve metabolic disorders, effects TRF on fecal microbiome, metabolome their diurnal oscillations in cancer have not been discussed. We performed 16S rRNA sequencing untargeted metabonomic feces prepared from models tumor-bearing BALB/c nude mice urethane-induced demonstrated for first time that significantly delayed growth tumors. Moreover, altered abundances clocks, as well rhythmicity, and/or C57BL/6J mice. results transplantation proved antitumor occur by regulating microbiota. Notably, Lactobacillus Bacillus were increased upon correlated most differential metabolites. Pathway enrichment analysis metabolites revealed mainly affected immune inflammatory processes, which might further explain how exerted its anticancer benefits. These findings underscore possibility microbiome/metabolome regulates following a paradigm.