Denosumab salvage therapy in an 11-year-old boy with locally recurrent unresectable giant cell tumor of the lumbar spine after surgery

• DOI: 10.1016/j.neuchi.2023.101427
• Publication Date: 2023-02-23T02:46:08Z
• Authors: Y. Luo; P. Xiu; H. Chen; J. Zeng; Y. Song; T. Li
• Keywords: Denosumab; Back Pain; Vertebra; Primary bone

Giant cell tumors (GCTs) of the bone are locally aggressive primary with a benign character. Spinal involvement is rare which accounts for approximately 5% all and it quite in lumbar spine. An 11-year-old boy patient presented pain low back bilateral extremities. Lumbar CT MRI revealed lytic lesion L4 vertebra corpus. The earned remarkable timely recovery 2 surgical interventions use denosumab. Surgical resection GCTs still preferable as initial treatment, denosumab should be utilized after tumor whether based on purpose prevention or treatment recurrence.