Dendritic cable with active spines: A modelling study in the spike-diffuse-spike framework

• DOI: 10.1016/j.neucom.2005.12.045
• Publication Date: 2006-02-08T18:25:23Z
• Authors: Yulia Timofeeva; Gabriel J. Lord; Stephen Coombes
• Keywords: 03 medical and health sciences; 0302 clinical medicine; 0103 physical sciences; 01 natural sciences; spike-diffuse-spike, dendritic spines, saltatory waves, noise

The spike-diffuse-spike (SDS) model describes a passive dendritic tree with active dendritic spines. Spine-head dynamics is modelled with a simple integrate-and-fire process, whilst communication between spines is mediated by the cable equation. Here we develop a computational framework that allows the study of multiple spiking events in a network of such spines embedded in a simple one-dimensional cable. This system is shown to support saltatory waves as a result of the discrete distribution of spines. Moreover, we demonstrate one of the ways to incorporate noise into the spine-head whilst retaining computational tractability of the model. The SDS model sustains a variety of propagating patterns.