The kinin B1 receptor mediates alloknesis in a murine model of inflammation

• DOI: 10.1016/j.neulet.2013.12.014
• Publication Date: 2013-12-16T07:15:27Z
• Authors: Jumian Feng; Yuanzhen Chen; Jialing Xiong; Xu Chen; Jiexian Liang; Wenjin Ji
• Keywords: Freund's adjuvant

Noxious stimuli and non-noxious mechanical stimuli elicit itch (alloknesis) instead of pain on skin lesions of patients with atopic dermatitis. We previously found that bradykinin evokes an itch-related scratching response through activation of kinin B1 receptor in skin inflamed using complete Freund's adjuvant. In this study we investigated whether alloknesis is evoked in CFA-inflamed skin and the involvement of kinin receptors. In our results, alloknesis was elicited four days after CFA-inflammation. Furthermore, pretreatment with a B1 receptor antagonist or μ-opioid receptor antagonist significantly reduced alloknesis. In contrast, treatment with a B2 receptor antagonist significantly increased alloknesis. These results suggest that the alloknesis response is mediated by the activation of kinin B1 receptor but antagonized by the B2 receptor in CFA-inflamed mice.