Caloric restriction increases hippocampal glutamate uptake and glutamine synthetase activity in Wistar rats

• DOI: 10.1016/j.neures.2009.04.004
• Publication Date: 2009-04-18T08:49:52Z
• Authors: Letícia Carina Ri...; André Quincozes-S...; Marina Concli Leite; Renata Torres Abib; Juliana Kleinkauf...; Regina Biasibetti; Liane Nanci Rotta; Susana T. Wofchuk; Marcos Luiz Santo...; Carlos-Alberto Go...; Carmem Gottfried
• Keywords: Caloric theory

Recent studies indicate that caloric restriction (CR) protects the central nervous system from several pathological conditions. The impairment of astroglial cell function, including glutamate uptake, glutamine synthetase (GS) activity and S100B secretion, may contribute to progression neurological disorders. present study aimed evaluate hippocampal astrocytic changes in response CR diet, measuring parameters, such as GS immunocontent GFAP S100B. Blood biochemical parameters were also analyzed. Rats (60-day old) fed ad libitum or on diets for 12 weeks. CR-fed rats showed approximately 16% less body weight gain than control rats. diet was able induce a significant increase uptake (23%) (26%). There no statistically differences either In summary, indicates modulates astrocyte functions by increasing activity, suggesting might exert its neuroprotective effects against brain illness modulation functions.