Maternal glyphosate-based herbicide exposure alters antioxidant-related genes in the brain and serum metabolites of male rat offspring

• DOI: 10.1016/j.neuro.2019.06.004
• Publication Date: 2019-06-18T15:09:31Z
• Authors: Janaina Sena de S...; Roberto Laureano-...; Roberto Hirochi H...; Rodrigo Rodrigues...; Kelen Carneiro Ol...; Ismael Dale Cotri...; Magnus Régios Dia...; Renata Marino Romano; Marco Aurélio Romano; Rui Monteiro de B...; Maria Izabel Chia...; Gisele Giannocco
• Keywords: Neuroglobin

In response to the rapid development of genetically engineered glyphosate-tolerant crops, use glyphosate-based herbicides (GBHs), in agriculture, has increased substantially. Currently, it is estimated that 747 million kg GBHs are applied per year. Although several epidemiological studies have demonstrated there health risks associated with GBH exposure, effects these chemicals on oxidative and inflammatory brain still unclear. fact, alterations processes could contribute neurological diseases, such as Alzheimer's disease autism spectrum disorders. The present study exposed pregnant rats evaluated changes expression genes related oxidnte defense inflammation monitored serum metabolome adult male offspring. Pregnant Wistar were administered distilled water or Roundup®, at either 5 50 mg/kg/day, (p.o.) from gestational day (GD) 18 postnatal (PND) 5. There was a significant increase gene levels Neuroglobin (Ngb - oxygen storage tissue protection) (105%, p = 0.031), Glutathione Peroxidase 1 (Gpx1 stress) (95%, 0.005), Prostaglandin-Endoperoxidase Synthase (Ptgs1 inflammation) (109%, 0.033) Hypoxia inducible factor subunit alpha (Hif1α sensor) (73%, 0.017), cerebellum PND90 perinatally mg GBH/kg/day. Moreover, both GBH-exposed groups displayed decrease Catalase (Cat (49%, 0.003; 31% 0.050, respectively) expression, cortex. Serum metabolites analyses, same animals each group, concentrations lysophosphatidylcholine phosphatidylcholine, which been neurodegenerative diseases. results suggest exposure during pregnancy alters oxidant defense, lipid metabolism. It plausible maternal lasting neuronal offspring later life.