Assessment of auditory function in rhesus monkeys (Macaca mulatta): effects of age and calorie restriction
Male
Aging
Perceptual Distortion
Matched-Pair Analysis
Otoacoustic Emissions, Spontaneous
Auditory Threshold
Macaca mulatta
03 medical and health sciences
0302 clinical medicine
Hearing
Reference Values
Evoked Potentials, Auditory, Brain Stem
Reaction Time
Animals
Energy Intake
Caloric Restriction
DOI:
10.1016/j.neurobiolaging.2003.09.006
Publication Date:
2003-12-31T07:13:11Z
AUTHORS (6)
ABSTRACT
Age-related alterations in auditory function were evaluated in adult male rhesus monkeys (Macaca mulatta) involved in a long-term study evaluating the effects of caloric restriction (CR) on aging. We assessed 26 monkeys in a control group fed a low fat, high fiber diet at approximately ad libitum levels and 24 monkeys in a CR group that were fed the same diet reduced in amount by 30% compared to age- and weight-matched controls. The following measures of auditory function were obtained while monkeys were maintained under anesthesia: (1) distortion product otoacoustic emissions (DPOAEs); (2) auditory brainstem responses (ABRs); and (3) middle latency responses (MLRs). All DPOAE measures and peak II amplitude significantly decreased with age, while peak IV latency and ABR threshold significantly increased with age. We found no significant effects of CR on any auditory parameters examined.
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