Novel N-terminal domain mutation in prion protein detected in 2 patients diagnosed with frontotemporal lobar degeneration syndrome

• DOI: 10.1016/j.neurobiolaging.2014.06.006
• Publication Date: 2014-06-16T18:28:38Z
• Authors: Livia Bernardi; Chiara Cupidi; Francesca Frangipane; Maria Anfossi; Maura Gallo; Maria Elena Conidi; Franca Vasso; Rosanna Colao; Gianfranco Puccio; Sabrina A.M. Curcio; Maria Mirabelli; Alessandra Clodomiro; Raffaele Di Lorenzo; Nicoletta Smirne; Raffaele Maletta; Amalia C. Bruni
• Keywords: Frontotemporal lobar degeneration

Prion protein gene mutations have been associated with clinical pictures mimicking neurodegenerative diseases different from inherited prion diseases (IPD). We report a novel missense P39L mutation in the N-terminal domain of prion protein in 2 patients affected by frontotemporal lobar degeneration syndrome, negative for mutations in genes causative of dementia. Neither the first carrier, a 67-year-old male in which the onset was a progressive non-fluent aphasia, nor the second carrier, a 78-year-old male affected by frontotemporal dementia and parkinsonism, showed any clinical or instrumental findings suggestive of IPD. Genetic screening of healthy controls and in silico analysis provide support for the potential pathogenicity of this variant. Patient phenotypes, unclassifiable as prion disease, may depend on the location of the mutation in the N-terminal domain, outside the amyloid core of pathologic prion protein, although further functional studies are required to determine whether and how this mutation exerts its pathogenic effect. However, genetic screening of prion protein gene becomes relevant in familial degenerative dementia, particularly in geographical areas with high IPD prevalence.