Imaging tau burden in dementia with Lewy bodies using [18F]-AV1451 positron emission tomography

• DOI: 10.1016/j.neurobiolaging.2020.11.006
• Publication Date: 2020-11-14T13:54:38Z
• Authors: Elijah Mak; Nicolas Nicastro; Maura Malpetti; George Savulich; Ajenthan Surendra...; Negin Holland; Luca Passamonti; P Simon Jones; Stephen F. Carter; Li Su; Young T. Hong; Tim D. Fryer; Guy B. Williams; Franklin Aigbirhio; James B. Rowe; John T. O'Brien
• Keywords: Lewy body; Colocalization; Binding potential

Alzheimer's disease (AD) pathology is frequently observed as a comorbidity in people with dementia Lewy bodies (DLB). Here, we evaluated the vivo distribution of tau burden and its influence on clinical phenotype DLB. Tau deposition was quantified using [18F]-AV1451 positron emission tomography DLB (n = 10), AD 27), healthy controls 14). A subset patients body diseases 4) also underwent [11C]-PK11195 to estimate microglial activation. BPND lower than across widespread regions. The medial temporal lobe distinguished from (AUC 0.87), negatively correlated Addenbrooke's Cognitive Examination-Revised Mini-Mental State Examination. There high degree colocalization between binding (p < 0.001). Our findings minimal confirm previous studies. Nevertheless, associations cognitive impairment suggest that may interact synergistically other pathologic processes aggravate severity