Development of BOLD signal hemodynamic responses in the human brain

• DOI: 10.1016/j.neuroimage.2012.06.054
• Publication Date: 2012-07-06T20:47:03Z
• Authors: Tomoki Arichi; Gianlorenzo Fagiolo; Marta Varela; Alejandro Melende...; Alessandro Allievi; Nazakat Merchant; Nora Tusor; Serena J. Counsell; Etienne Burdet; Christian F. Beck...; A. David Edwards
• Keywords: Haemodynamic response; Stimulus (psychology); Blood-oxygen-level dependent; Brain Development; Human brain

In the rodent brain hemodynamic response to a brief external stimulus changes significantly during development. Analogous in human infants would complicate determination and use of function (HRF) for functional magnetic resonance imaging (fMRI) developing populations. We aimed characterize HRF before after normal time birth using rapid sampling blood oxygen level dependent (BOLD) signal. A somatosensory an event related experimental design were used collect data from 10 healthy adults, 15 sedated at term corrected post menstrual age (PMA) (median 41+1 weeks), preterm PMA 34+4 weeks). positive amplitude waveform was identified across all subject groups, with systematic maturational trend terms decreasing time-to-peak increasing peak associated age. Application age-appropriate models fMRI improved precision analysis. These findings support notion structured development brain's stimuli last trimester gestation beyond.