Disentangling different functional roles of evoked K-complex components: Mapping the sleeping brain while quenching sensory processing

• DOI: 10.1016/j.neuroimage.2013.10.030
• Publication Date: 2013-10-27T00:18:54Z
• Authors: Marco Laurino; Danilo Menicucci; Andrea Piarulli; Francesca Mastorci; Remo Bedini; Paolo Allegrini; Angelo Gemignani
• Keywords: Adult; Cerebral Cortex; Male; 0301 basic medicine; Brain Mapping; Adult; Biological Clocks; Brain Mapping; Cerebral Cortex; Electroencephalography; Evoked Potentials; Female; Humans; Male; Nerve Net; Sleep Stages; Young Adult; Sensation; Consciousness; Sensation; Electroencephalography; Young Adult; 03 medical and health sciences; Biological Clocks; NREM sleep; Humans; K-complex; Slow oscillation; Female; Bistability; Sleep Stages; Nerve Net; Evoked Potentials

During non-REM sleep the largest EEG response evoked by sensory stimulation is the K-complex (eKC), composed of an initial positive bump (P200) followed by a bistable cortical response: a giant negative deflection (N550) and a large positive one (P900), respectively reflecting down states and up states of < 1 Hz oscillations.Sensory-modality-independent topology of N550 and P900, with maximal detection rate on fronto-central areas, has been consistently reported, suggesting that sensory inputs arise to the cortex avoiding specific primary sensory areas. However, these studies neglected latencies of all KC components as a function of electrode sites.Our aim is to identify, component by component, which topological/dynamical properties of eKCs depend on stimulus modality and which are mainly related to local cortical properties. We measured temporal and morphological features of acoustic, tactile and visual eKCs to disentangle specific sensory excitatory activities from aspecific responses due to local proneness to bistability, measured by means of the N550 descending steepness (synchronization in falling into down state).While confirming the sensory-modality independence of N550 and P900 topology with maximal detection rate in fronto-central areas, four main original results emerge from this study: (i) the topology of P200 latency depends on the sensory modality with earliest waves in the stimulation-related primary sensory areas; (ii) P200 rapidly travels as a cortical excitation; (iii) P200-like excitations when KCs are not evoked are detected over the scalp with significantly smaller amplitudes in fronto-central areas, compared to eKC P200s; and (iv) N550 latency mirrors its mean local steepness which is a function of topological proneness to bistability.From these results we can describe the emergence N550/P900 complex as the interplay between a waxing P200 cortical travel and higher fronto-central proneness to bistability.In conclusion, eKCs exhibit a physiological dichotomy: P200 acts as a traveling cortical excitation whose function is to induce the bistable cortical response (N550/P900), which in turn is crucial for maintaining sleep and unconsciousness.