Tissue magnetic susceptibility mapping as a marker of tau pathology in Alzheimer's disease

• DOI: 10.1016/j.neuroimage.2017.08.003
• Publication Date: 2017-08-05T00:30:16Z
• Authors: J. O'Callaghan; H. Holmes; N. Powell; J.A. Wells; O. Ismail; I.F. Harrison; B. Siow; R. Johnson; Z. Ahmed; A. Fisher; S. Meftah; M.J. O'Neill; T.K. Murray; E.C. Collins; K. Shmueli; M.F. Lythgoe
• Keywords: Quantitative Susceptibility Mapping; Tauopathy; Grey matter; Tau protein

Alzheimer's disease is connected to a number of other neurodegenerative conditions, known collectively as 'tauopathies', by the presence aggregated tau protein in brain. Neuroinflammation and oxidative stress AD are associated with pathology both breakdown axonal sheaths white matter tracts excess iron accumulation grey brain regions. Despite identification myelin concentration major sources contrast quantitative susceptibility maps brain, sensitivity this technique has yet be explored. In study, we perform Quantitative Susceptibility Mapping (QSM) T2* mapping rTg4510, mouse model tauopathy, vivo ex vivo. Significant correlations were observed between histological measures content mean regional magnetic values. These results suggest that sensitive tissue concentrations across different regions Differences detected corpus callosum, striatum, hippocampus thalamus rTg4510 mice relative wild type controls. The neurofibrillary tangles was found low intermediate these indicating QSM may useful biomarker for early stage detection diseases.