Imaging of focal seizures with Electrical Impedance Tomography and depth electrodes in real time

• DOI: 10.1016/j.neuroimage.2021.117972
• Publication Date: 2021-03-20T23:11:13Z
• Authors: Anna Witkowska-Wr...; Kirill Aristovich; Abbe Crawford; Justin D. Perkins; David Holder
• Keywords: Electrical Impedance Tomography; Stereoelectroencephalography

Intracranial EEG is the current gold standard technique for localizing seizures surgery, but it can be insensitive to tangential dipole or distant sources. Electrical Impedance Tomography (EIT) offers a novel method improve coverage and seizure onset localization. The feasibility of EIT has been previously assessed in computer simulation, which revealed an improved accuracy detection with compared intracranial EEG. In this study, slow impedance changes, evoked by cell swelling occurring over seconds, were reconstructed real time frequency division multiplexing using depth subdural electrodes swine model epilepsy. allowed generate repetitive images ictal events at similar course fMRI without its significant limitations. was recorded system consisting 32 parallel sources 64 voltage recorders. Seizures triggered injection benzylpenicillin (BPN) five pigs caused peak increase 3.4 ± 1.5 mV 9.5 3% (N =205 seizures); signal change seen already after single, first seizure. enabled reconstruction 9 mm from BPN cannula 7.5 1.1 closest SEEG contact (p<0.05, n =37 focal three pigs) could address problems sampling error amplitude correlated spread on (p <<0.001, =37). results presented here suggest that combining monitoring potential diagnostic yield epileptic patients become vital tool improving our understanding