Clinical connectome fingerprints of cognitive decline

• DOI: 10.1016/j.neuroimage.2021.118253
• Publication Date: 2021-06-09T08:02:26Z
• Authors: Pierpaolo Sorrentino; Rosaria Rucco; Anna Lardone; Marianna Liparoti; Emahnuel Troisi L...; Carlo Cavaliere; Andrea Soricelli; Viktor Jirsa; Giuseppe Sorrentino; Enrico Amico
• Keywords: Magnetoencephalography; Human Connectome Project

Brain connectome fingerprinting is rapidly rising as a novel influential field in brain network analysis. Yet, it still unclear whether connectivity fingerprints could be effectively used for mapping and predicting disease progression from human data. We hypothesize that dysregulation of activity would reflect worse subject identification. propose framework, Clinical Connectome Fingerprinting, to detect individual features clinical populations. show "clinical fingerprints" can map variations between elderly healthy subjects patients with mild cognitive impairment functional connectomes extracted magnetoencephalography find identifiability reduced compared controls, these are predictive the Mini-Mental State Examination (MMSE) score patients. hope proposed methodology help bridging gap biomarkers dysfunction large-scale networks.