Gene expression associated with individual variability in intrinsic functional connectivity

• DOI: 10.1016/j.neuroimage.2021.118743
• Publication Date: 2021-11-17T16:50:53Z
• Authors: Liangfang Li; Yongbin Wei; Jinbo Zhang; Junji Ma; Yangyang Yi; Yue Gu; Liman Man Wai Li; Ying Lin; Zhengjia Dai
• Keywords: Human brain

It has been revealed that intersubject variability (ISV) in intrinsic functional connectivity (FC) is associated with a wide variety of cognitive and behavioral performances. However, the underlying organizational principle ISV FC its related gene transcriptional profiles remain unclear. Using resting-state fMRI data from Human Connectome Project (299 adult participants) microarray expression Allen Brain Atlas, we conducted transcription-neuroimaging association study to investigate spatial configurations their associations profiles. We found multimodal cortices showed greatest FC, while unimodal subcortical areas least ISV. Importantly, partial squares regression analysis genes human accelerated regions (HARs) could explain 31.29% variation distribution FC. The top-related were enriched for development central nervous system, neurogenesis cellular components synapse. Moreover, observed effect profile on heterogeneous was significantly mediated by cerebral blood flow configuration. These findings highlighted arrangement coupling variations supply.