Multi‐parameter quantitative mapping of R1, R2*, PD, and MTsat is reproducible when accelerated with Compressed SENSE

• DOI: 10.1016/j.neuroimage.2022.119092
• Publication Date: 2022-03-11T16:39:56Z
• Authors: Ronja C. Berg; Tobias Leutritz; Nikolaus Weiskopf; Christine Preibisch
• Keywords: Repeatability

Multi-parameter mapping (MPM) magnetic resonance imaging (MRI) provides quantitative estimates of the longitudinal and effective transverse relaxation rates R1 R2*, proton density (PD), magnetization transfer saturation (MTsat). Thereby, MPM enables better comparability across sites time than conventional weighted MRI. However, for MPM, several contrasts must be acquired, resulting in prolonged measurement durations thus preventing MPM's application clinical routines. State-of-the-art acceleration techniques such as Compressed SENSE (CS), a combination compressed sensing sensitivity encoding, can used to reduce scan MPM. accuracy precision parameter maps have not been systematically evaluated. In this study, we therefore investigated effect CS on fidelity reproducibility acquisitions. five healthy volunteers phantom, compared metrics acquired without acceleration, with standard (SENSE factor 2.5), factors 4 6 using 32-channel head coil. We evaluated repeatability accelerated data from three sessions gray white matter volumes-of-interest (VOIs). Accelerated provided precise accurate maps. For most parameters, results CS-accelerated protocols correlated more strongly non-accelerated protocol SENSE-accelerated protocols. Furthermore, VOIs contrasts, coefficients variation were lower when calculated different accelerations within single session same method. These suggest that up at least yields reproducible are highly comparable those acceleration. considerably duration R1, PD, MTsat mapping, is promising applications