The overlapping modular organization of human brain functional networks across the adult lifespan

• DOI: 10.1016/j.neuroimage.2022.119125
• Publication Date: 2022-03-21T18:03:00Z
• Authors: Yue Gu; Liangfang Li; Yining Zhang; Junji Ma; Chenfan Yang; Yu Xiao; Ni Shu; Cam CAN; Ying Lin; Zhengjia Dai
• Keywords: Modularity; Cognitive flexibility; Human brain; Human Connectome Project; Brain Function

Previous studies have demonstrated that the brain functional modular organization, which is a fundamental feature of human brain, would change along adult lifespan. However, these assumed each region belonged to single module, although there has been convergent evidence supporting existence overlap among modules in brain. To reveal how age affects overlapping this study applied an module detection algorithm requires no prior knowledge resting-state fMRI data healthy cohort (N = 570) aged from 18 88 years old. A series measures were derived delineate characteristics structure and set nodes (brain regions participating two or more modules) identified participant. Age-related regression analyses on found linearly decreasing trends modularity similarity. The number was increasing with age, but increment not even over In addition, across lifespan within group, nodal probability consistently had positive correlations both gradient flexibility. Further, by correlation mediation analyses, we showed influence memory-related cognitive performance might be explained organization. Together, our results revealed age-related decreased segregation organization perspective, could provide new insight into changes function such performance.