Developmental changes in neonatal hemodynamics during tactile stimulation using whole-head functional near-infrared spectroscopy

• DOI: 10.1016/j.neuroimage.2023.120465
• Publication Date: 2023-11-21T05:41:41Z
• Authors: Yutaka Fuchino; Ikuko Kato; Yinmon Htun; Yuji Takano; Yukihiko Konishi; Kosuke Koyano; Shinji Nakamura; Naoki Tanaka; Takashi Kusaka; Yukuo Konishi
• Keywords: Adult; Infancy; Spectroscopy, Near-Infrared; Infant, Newborn; Hemodynamics; Motor Cortex; Infant; Neurosciences. Biological psychiatry. Neuropsychiatry; Somatosensory stimulation; Hemoglobins; Near-infrared spectroscopy; Touch; Oxyhemoglobins; Humans; Developmental changes; Neurovascular coupling; RC321-571

Neural-activity-associated hemodynamic changes have been used to noninvasively measure brain function in the early developmental stages. However, the temporal changes in their hemodynamics are not always consistent with adults. Studies have not evaluated developmental changes for a long period using the same stimuli; therefore, this study examined the normalized relative changes in oxygenated hemoglobin (Δ[oxy-Hb]) in full-term infants and compared them with neonates up to 10 months of age during the administration of tactile vibration stimuli to their limbs using whole-head functional near-infrared spectroscopy. The time to peak of normalized Δ[oxy-Hb] was not affected by age. The amplitude of normalized Δ[oxy-Hb] showed an effect of age in broader areas, including sensorimotor-related but excluding supplementary motor area; the amplitude of normalized Δ[oxy-Hb] decreased the most in the 1-2-month-old group and later increased with development. We hypothesized that these results may reflect developmental changes in neural activity, vasculature, and blood oxygenation.