Happy people are always similar: The evidence from brain morphological and functional inter-subject correlations

• DOI: 10.1016/j.neuroimage.2024.120690
• Publication Date: 2024-06-15T03:20:08Z
• Authors: Zixi Li; Keying Jiang; Ye Zhu; Hanxiao Du; Hohjin Im; Yingying Zhu; Lei Feng; Wenwei Zhu; Guang Zhao; Xuji Jia; Ying Hu; Haidong Zhu; Qiong Yao; He Wang; Qiang Wang
• Keywords: Male; Adult; Brain Mapping; Adolescent; Face-matching task; Inter-subject representational similarity analysis; Happiness; 05 social sciences; Brain; Neurosciences. Biological psychiatry. Neuropsychiatry; Fear; Amygdala; Magnetic Resonance Imaging; Facial Expression; Aggression; Young Adult; Affect; Humans; Female; 0501 psychology and cognitive sciences; Facial Recognition; RC321-571; Personality

A fundamental question in the study of happiness is whether there is neural evidence to support a well-known hypothesis that happy people are always similar while unfortunate people have their own misfortunes. To investigate this, we employed several happiness-related questionnaires to identify potential components of happiness, and further investigated and confirmed their associations with personality, mood, aggressive behaviors, and amygdala reactivity to fearful faces within a substantial sample size of college students (n = 570). Additionally, we examined the functional and morphological similarities and differences among happy individuals using the inter-subject representational similarity analysis (IS-RSA). IS-RSA emphasizes the geometric properties in a high-dimensional space constructed by brain or behavioral patterns and focuses on individual subjects. Our behavioral findings unveiled two factors of happiness: individual and social, both of which mediated the effect of personality traits on individual aggression. Subsequently, mood mediated the impact of happiness on aggressive behaviors across two subgroup splits. Functional imaging data revealed that individuals with higher levels of happiness exhibited reduced amygdala reactivity to fearful faces, as evidenced by a conventional face-matching task (n = 104). Moreover, IS-RSA demonstrated that these participants manifested similar neural activation patterns when processing fearful faces within the visual pathway, but not within the emotional network (e.g., amygdala). Morphological observations (n = 425) indicated that individuals with similar high happiness levels exhibited comparable gray matter volume patterns within several networks, including the default mode network, fronto-parietal network, visual network, and attention network. Collectively, these findings offer early neural evidence supporting the proposition that happy individuals may share common neural characteristics.