The connectivity-based architecture of the human piriform cortex

• DOI: 10.1016/j.neuroimage.2024.120747
• Publication Date: 2024-07-20T01:07:09Z
• Authors: F. Zahnert; U. Kleinholdermann; M. Belke; B. Keil; K. Menzler; D.J. Pedrosa; L. Timmermann; T. Kircher; I. Nenadić; S. Knake
• Keywords: Piriform cortex; Human brain

The anatomy of the human piriform cortex (PC) is poorly understood. We used a bimodal connectivity-based-parcellation approach to investigate subregions PC and its connectional differentiation from amygdala. One hundred (55 % female) genetically unrelated subjects Human Connectome Project were included. A region interest (ROI) was delineated bilaterally covering amygdala, functional structural connectivity this ROI with whole gray matter computed. Spectral clustering performed obtain bilateral parcellations at granularities k = 2-10 clusters combined Validity assessed via their mean individual-to-group similarity per adjusted rand index (ARI). Individual-to-group higher than chance in both modalities all solutions. amygdala clearly distinguished parcellations, olfactory connectionally more similar PC. At granularities, an anterior ventrotemporal posterior frontal cluster emerged within PC, as well additional temporal boundary. Functional also showed cluster, observed less consistency. Results parcellations. Consistent results obtained validation cohort. Distinction including subregions, possible based on alone. canonical fronto-temporal boundary reproduced All are freely available.