The critical mediating roles of the middle temporal gyrus and ventrolateral prefrontal cortex in the dynamic processing of interpersonal emotion regulation

• DOI: 10.1016/j.neuroimage.2024.120789
• Publication Date: 2024-08-17T15:50:58Z
• Authors: Jiazheng Wang; Zhenzhen Yang; Benjamin Klugah-B...; Tao Zhang; Jiemin Yang; JiaJin Yuan; Bharat B Biswal
• Keywords: Ventrolateral prefrontal cortex (VLPFC); Male; Adult; Brain Mapping; Emotions; Dynamic functional connectivity (DFC); Prefrontal Cortex; Neurosciences. Biological psychiatry. Neuropsychiatry; Middle temporal gyrus (MTG); Magnetic Resonance Imaging; Temporal Lobe; Emotional Regulation; Interpersonal emotion regulation (IER); Young Adult; Connectome; Humans; Female; Interpersonal Relations; Empathy; Nerve Net; RC321-571

Interpersonal emotion regulation (IER) is a crucial ability for effectively recovering from negative emotions through social interaction. It has been emphasized that the empathy network, cognitive control network, and affective generation network sustain the deployment of IER. However, the temporal dynamics of functional connectivity among these networks of IER remains unclear. This study utilized IER task-fMRI and sliding window approach to examine both the stationary and dynamic functional connectivity (dFC) of IER. Fifty-five healthy participants were recruited for the present study. Through clustering analysis, four distinct brain states were identified in dFC. State 1 demonstrated situation modification stage of IER, with strong connectivity between affective generation and visual networks. State 2 exhibited pronounced connectivity between empathy network and both cognitive control and affective generation networks, reflecting the empathy stage of IER. Next, a 'top-down' pattern is observed between the connectivity of cognitive control and affective generation networks during the cognitive control stage of state 3. The affective response modulation stage of state 4 mainly involved connections between empathy and affective generation networks. Specifically, the degree centrality of the left middle temporal gyrus (MTG) mediated the association between one's IER tendency and the regulatory effects in state 2. The betweenness centrality of the left ventrolateral prefrontal cortex (VLPFC) mediated the association between one's IER efficiency and the regulatory effects in state 3. Altogether, these findings revealed that dynamic connectivity transitions among empathy, cognitive control, and affective generation networks, with the left VLPFC and MTG playing dominant roles, evident across the IER processing.