Direct Electrical Stimulation of the Human Entorhinal Region and Hippocampus Impairs Memory
03 medical and health sciences
Epilepsy
0302 clinical medicine
Memory
General Neuroscience
Deep Brain Stimulation
Task Performance and Analysis
Entorhinal Cortex
Humans
Hippocampus
Spatial Memory
DOI:
10.1016/j.neuron.2016.10.062
Publication Date:
2016-12-07T17:53:28Z
AUTHORS (20)
ABSTRACT
Deep brain stimulation (DBS) has shown promise for treating a range of brain disorders and neurological conditions. One recent study showed that DBS in the entorhinal region improved the accuracy of human spatial memory. Based on this line of work, we performed a series of experiments to more fully characterize the effects of DBS in the medial temporal lobe on human memory. Neurosurgical patients with implanted electrodes performed spatial and verbal-episodic memory tasks. During the encoding periods of both tasks, subjects received electrical stimulation at 50 Hz. In contrast to earlier work, electrical stimulation impaired memory performance significantly in both spatial and verbal tasks. Stimulation in both the entorhinal region and hippocampus caused decreased memory performance. These findings indicate that the entorhinal region and hippocampus are causally involved in human memory and suggest that refined methods are needed to use DBS in these regions to improve memory.
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CITATIONS (201)
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