Interoception of breathing and its relationship with anxiety

• DOI: 10.1016/j.neuron.2021.09.045
• Publication Date: 2021-10-22T01:19:53Z
• Authors: Olivia K. Harrison; Laura Köchli; Stephanie Marino; Roger Luechinger; Franciszek Hennel; Katja Brand; Alexander J. Hess; Stefan Frässle; Sandra Iglesias; Fabien Vinckier; Frederike H. Petz...; Samuel J. Harrison; Klaas E. Stephan
• Keywords: Interoception; Predictability

Interoception, the perception of internal bodily states, is thought to be inextricably linked affective qualities such as anxiety. Although interoception spans sensory metacognitive processing, it not clear whether anxiety differentially related these processing levels. Here we investigated this question in domain breathing, using computational modeling and high-field (7 T) fMRI assess brain activity relating dynamic changes inspiratory resistance varying predictability. Notably, anterior insula was associated with both breathing-related prediction certainty errors, suggesting an important role representing updating models body. Individuals low versus moderate traits showed differential for certainty. Multi-modal analyses data from fMRI, assessments metacognition, questionnaires demonstrated that anxiety-interoception links span all levels perceptual sensitivity strong effects seen at higher interoceptive processes.