Alzheimer’s disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model

• DOI: 10.1016/j.neuron.2024.09.006
• Publication Date: 2024-09-30T14:36:01Z
• Authors: Gillian K. Carling; Li Fan; Nessa R. Foxe; Kendra Norman; Man Ying Wong; Daphne Zhu; Carlo Corona; Agnese Razzoli; Fangmin Yu; Allan Yarahmady; Pearly Ye; Hao Chen; Yige Huang; Sadaf Amin; Rebecca Sereda; Chloe Lopez-Lee; Emmanouil Zachari...; Xiaoying Chen; Jielin Xu; Feixiong Cheng; Evripidis Gavathi...; Ana Maria Cuervo; David M. Holtzman; Sue-Ann Mok; Subhash C. Sinha; Simone Sidoli; Rajiv R. Ratan; Wenjie Luo; Shiaoching Gong; Li Gan
• Keywords: Tauopathy; Senescence

The strongest risk factors for late-onset sporadic Alzheimer's disease (AD) include the ε4 allele of apolipoprotein E (APOE), R47H variant triggering receptor expressed on myeloid cells 2 (TREM2), and female sex. Here, we combine APOE4 TREM2