Developmental expression and function analysis of protein tyrosine phosphatase receptor type D in oligodendrocyte myelination

• DOI: 10.1016/j.neuroscience.2015.08.062
• Publication Date: 2015-09-01T03:58:53Z
• Authors: Q. Zhu; Z. Tan; S. Zhao; H. Huang; X. Zhao; X. Hu; Y. Zhang; C.B. Shields; N. Uetani; M. Qiu
• Keywords: 0303 health sciences; Blotting, Western; Receptor-Like Protein Tyrosine Phosphatases, Class 2; Brain; Cell Differentiation; Mice, Transgenic; Motor Activity; Evoked Potentials, Motor; Immunohistochemistry; Transcranial Magnetic Stimulation; Cuprizone; Disease Models, Animal; Oligodendroglia; 03 medical and health sciences; Spinal Cord; Mutation; Animals; In Situ Hybridization; Demyelinating Diseases

Receptor protein tyrosine phosphatases (RPTPs) are extensively expressed in the central nervous system (CNS), and have distinct spatial and temporal patterns in different cell types during development. Previous studies have demonstrated possible roles for RPTPs in axon outgrowth, guidance, and synaptogenesis. In the present study, our results revealed that protein tyrosine phosphatase, receptor type D (PTPRD) was initially expressed in mature neurons in embryonic CNS, and later in oligodendroglial cells at postnatal stages when oligodendrocytes undergo active axonal myelination process. In PTPRD mutants, oligodendrocyte differentiation was normal and a transient myelination delay occurred at early postnatal stages, indicating the contribution of PTPRD to the initiation of axonal myelination. Our results also showed that the remyelination process was not affected in the absence of PTPRD function after a cuprizone-induced demyelination in adult animals.