Altered functional connectivity during performance feedback processing in multiple sclerosis

• DOI: 10.1016/j.nicl.2022.103287
• Publication Date: 2022-12-07T17:02:00Z
• Authors: Christopher J. Cagna; Ahmet O. Ceceli; Joshua Sandry; Jamil P. Bhanji; Elizabeth Tricomi; Ekaterina Dobryakova
• Keywords: Neurotypical

Effective learning from performance feedback is vital for adaptive behavior regulation necessary successful cognitive performance. Yet, how this operates in clinical groups that experience dysfunction not well understood. Multiple sclerosis (MS) an autoimmune, degenerative disease of the central nervous system characterized by physical and dysfunction. A highly prevalent impairment MS fatigue (CF). CF associated with altered functioning within cortico-striatal regions also facilitate feedback-based neurotypical (NT) individuals. Despite overlap, research about MS, its neural underpinnings, sensitivity to CF, are all lacking. The present study investigated ability as function connectivity. NT participants completed a functional magnetic resonance imaging (fMRI) paired-word association task during which they received trial-by-trial monetary, non-monetary, uninformative feedback. reporting greater throughout task, displayed comparable NTs, suggesting preserved group. Both recruited ventral striatum (VS), caudate nucleus, ventromedial prefrontal cortex response receipt feedback, people recruit learning. However, compared participants, stronger connectivity between VS task-relevant regions, including left angular gyrus right superior temporal gyrus, receipt. Results indicate may interfere MS. Nonetheless, alternative connections assist form These findings have implications rehabilitation treatments incorporate remediate populations.