Transdiagnostic brain correlates of self-reported trait impulsivity: A dimensional structure-symptom investigation

• DOI: 10.1016/j.nicl.2023.103423
• Publication Date: 2023-04-28T16:44:28Z
• Authors: Anna-Chiara Schaub; Marc Vogel; Undine E. Lang; Stefan Kaiser; Marc Walter; Marcus Herdener; Johannes Wrege; Matthias Kirschner; André Schmidt
• Keywords: Anhedonia; Barratt Impulsiveness Scale

Impulsivity transcends psychiatric diagnoses and is often related to anhedonia. This ad hoc cross-sectional investigation explored 1) whether self-reported trait impulsivity mapped onto a common structural brain substrate across healthy controls (HCs) patients, 2) in more exploratory fashion, anhedonia were each other shared overlapping correlates. Structural magnetic resonance imaging (sMRI) datasets from 234 participants including HCs (n = 109) patients with opioid use disorder (OUD, n 22), cocaine (CUD, 43), borderline personality (BPD, 45) schizophrenia (SZ, 15) included. Trait was measured the Barratt Impulsiveness Scale (BIS-11) subscore of Beck Depression Inventory (BDI). BIS-11 global score data available for entire sample, while on 2nd order factors attentional, motor non-planning additionally hand subsample consisting HCs, OUD BPD 116). Voxel-based morphometry analyses conducted identifying dimensional associations between grey matter volume impulsivity/anhedonia. Partial correlations further performed test relationships their corresponding volumetric substrates. Volume left opercular part inferior frontal gyrus (IFG) negatively sample specifically patients. Across expression correlated putamen volume. Although there no relationship all only positively associated attentional impulsivity. Finally, also IFG linked anhedonia-associated putamen. Our findings suggest critical role substance disorder, SZ. Preliminary suggests that are reductions