Leishmania chagasi naturally resistant to nitric oxide isolated from humans and dogs with visceral leishmaniasis in Brazil

• DOI: 10.1016/j.niox.2012.04.004
• Publication Date: 2012-04-30T16:39:49Z
• Authors: P.L. Santos; R.V. Costa; J.M. Braz; L.F.V.C. Santos; A.C. Batista; C.R.O. Vasconcelos; M.R. Rangel; A. Ribeiro de Jesus; T.R. de Moura; P.T.G. Leopoldo; R.P. Almeida
• Keywords: Leishmania chagasi; Leishmania braziliensis

Nitric oxide (NO) plays an important role as a leishmanicidal agent in murine macrophages. NO resistant Escherichia coli and Mycobacterium tuberculosis have been associated with poor outcomes of their resulting diseases. Leishmania braziliensis has also identified exacerbates the clinical course human leishmaniasis. We report, for first time, natural resistance chagasi promastigotes to NO. These parasites were isolated from humans dogs visceral demonstrate that this profile was greater survival capacity parasite burden macrophages, independent activation after by IFN-γ LPS.