Assessment of l-arginine asymmetric 1 dimethyl (ADMA) in early-onset and late-onset (severe) preeclampsia

• DOI: 10.1016/j.niox.2013.07.006
• Publication Date: 2013-07-19T22:49:07Z
• Authors: Patrícia Nessrall...; Lara Carvalho Godoi; Letícia Gonçalves...; Karina Braga Gomes; Luci Maria Dusse
• Keywords: Cancer Research; Physiology; Nitric oxide synthase; Clinical Biochemistry; Nitric oxide; Enzyme-Linked Immunosorbent Assay; Preeclampsia; Arginine; Nitric Oxide; Biochemistry; ADMA; 03 medical and health sciences; 0302 clinical medicine; Pre-Eclampsia; Pregnancy; Case-Control Studies; Humans; Female

Preeclampsia (PE) is characterized by hypertension and proteinuria. It has been classified in early or late according to gestational age at the onset of disease. Endothelial dysfunction plays a crucial part in its pathogenesis. NO is a potent vasodilator and ADMA is its endogenous inhibitor. We have assessed maternal ADMA levels. ADMA were increased in early [0.66 μmol/L] versus late sPE [0.47 μmol/L] (P=0.001) and versus normotensive pregnant [0.48 μmol/L] (P=0.001). Our findings suggest that high ADMA levels in early sPE could compromise NO synthesis contributing to endothelial dysfunction, leading to impaired placentation and the onset of this disease.