Evolution of the mdx mouse cardiomyopathy: physiological and morphological findings

• DOI: 10.1016/j.nmd.2004.04.007
• Publication Date: 2004-08-04T20:12:11Z
• Authors: John G. Quinlan; Harvey S. Hahn; Brenda L. Wong; John N. Lorenz; Alexandra S. Wenisch; Linda S. Levin
• Keywords: Male; 0301 basic medicine; Aging; Analysis of Variance; Myocardium; Heart; 3. Good health; Mice, Inbred C57BL; Disease Models, Animal; Mice; 03 medical and health sciences; Echocardiography; Mice, Inbred mdx; Animals; Female; Cardiomyopathies

Heart failure is a major cause of death in boys with Duchenne muscular dystrophy. In order to determine if the cardiac function of the mdx mouse is similarly disturbed, we performed murine echocardiograms and left heart catheterization studies, along with morphometric analysis of cardiac fibrosis. Serial echocardiograms in mdx mice revealed the evolution from normal cardiac function in young mice to a dilated cardiomyopathy in adult mice. Very old mdx mice exhibited a widespread but patchy increase in ventricular wall fibrosis. These results show that the mdx cardiac function is more impaired than was previously thought and shares important clinical features with the cardiomyopathy of Duchenne muscular dystrophy.