Association of dietary patterns with diabetes-related comorbidities varies among diabetes endotypes

• DOI: 10.1016/j.numecd.2023.12.026
• Publication Date: 2024-01-05T16:56:12Z
• Authors: Katharina S. Weber; Sabrina Schlesinger; Alexander Lang; Klaus Straßburger; Haifa Maalmi; Anna Zhu; Oana-Patricia Zah...; Alexander Strom; Gidon J. Bönhof; Janina Goletzke; Sandra Trenkamp; Robert Wagner; Anette E. Buyken; Wolfgang Lieb; Michael Roden; Christian Herder; M. Roden; H. Al-Hasani; B. Belgardt; E. Lammert; G. Bönhof; G. Geerling; C. Herder; A. Icks; K. Jandeleit-Dahm; J. Kotzka; O. Kuß; W. Rathmann; S. Schlesinger; V. Schrauwen-Hind...; J. Szendroedi; S. Trenkamp; R. Wagner
• Keywords: Association (psychology)

Background and Aims Differences of dietary pattern adherence across the novel diabetes endotypes are unknown. This study assessed to pre-specified patterns their associations with cardiovascular risk factors, kidney function, neuropathy among endotypes. Methods Results The cross-sectional analysis included 765 individuals recent-onset (67%) prevalent (33%) from German Diabetes Study (GDS) allocated into severe autoimmune (SAID, 35%), insulin-deficient (SIDD, 3%), insulin-resistant (SIRD, 5%), mild obesity-related (MOD, 28%), age-related (MARD, 29%). Adherence a Mediterranean diet score (MDS), Dietary Approaches Stop Hypertension (DASH) score, overall plant-based (PDI), healthful (hPDI) unhealthful index (uPDI) was derived food frequency questionnaire associated using multivariable linear regression analysis. in between were generalized mixed models. People MARD showed highest, those SIDD MOD lowest hPDI. MDS, DASH, PDI, hPDI inversely high-sensitivity C-reactive protein (hsCRP) people (ß (95%CI): -9.18% (-15.61; -2.26); -13.61% (-24.17; -1.58); -19.15% (-34.28; -0.53); -16.10% (-28.81; -1.12), respectively). PDIs LDL cholesterol SAID, SIRD, MOD. Conclusions Minor differences (in particular for hPDI) markers diabetes-related complications (e.g. hsCRP) observed So far, evidence is insufficient derive endotype-specific recommendations. Trial registration Clinicaltrials.gov: NCT01055093.