Recent advances in targeted drug delivery using metal-organic frameworks: toxicity and release kinetics

• DOI: 10.1016/j.nxnano.2023.100027
• Publication Date: 2023-12-10T15:46:26Z
• Authors: Sanjeev Gautam; Ishita Lakhanpal; Lidiya Sonowal; Navdeep Goyal
• Keywords: Targeted drug delivery

Targeted drug delivery using metal-organic frameworks (MOFs) has become an area of significant interest due to their unique ability change configuration and porosity. MOFs offer a tuneable porous hybridization that enhances interactions allows for greater loadings. The drugs are enclosed within nanoparticles designed protect them against enzymatic chemical degradation, ensuring targeted specific locations with precise dosages. This technology demonstrated immense potential revolutionize delivery. However, as the number nanomaterial varieties uses continues grow, there is pressing need investigate toxicity release kinetics. Cytotoxicity, pilot project test, emerged crucial diagnostic evaluation medical equipment. Investigations underway describe effects minimal exposure address possible after release. Despite benefits in delivery, kinetics remain poorly understood. Researchers currently exploring different strategies optimize performance while minimizing adverse effects. Recent advances have shown great promise, but must be thoroughly evaluated before they can safely used clinical applications.